Age-Related Inflammation

Inflammation is a natural part of our body’s immune response. When injury or infection occurs, it promotes healing and provides protection. As we age, however, low-grade chronic systemic inflammation increases, causing a negative effect. Recognition of this condition has led to a promising new field of research into what’s called Inflammaging.

Inflammaging is believed to accelerate the process of biological aging and impact many age-related diseases. Growing evidence has shown a potential link between chronic inflammation and diseases such as Alzheimer's disease, atherosclerosis, heart disease, age-related macular degeneration and osteoporosis. (1)

A recent study in the Proceedings of the National Academy of Sciences (PNAS) also points to chronic inflammation as the reason injured bones do not heal as well with age. Researchers discovered that age-related growth in immune signals impedes the ability of stem cells to multiply. This reduced number hinders the stem cells’ ability to rebuild bone after an injury. (2)

Our signature, age-related anti-inflammation treatment is ideal for patients who are experiencing fatigue, decreased mobility, and other chronic conditions due to systemic inflammation. It may also be beneficial as a form of preventative medicine before symptoms of age-related inflammatory diseases are identified. We offer high-yield adult stem cell therapy delivered intravenously to provide a systemic anti-inflammatory effect to promote tissue healing, increased energy and anti-aging.

What Can Stem Cell Therapy Do for age-related inflammation?

At Okyanos, we treat patients with stromal vascular fraction, or SVF, which comes from your own adipose (fat) tissue. Through a specialized, enzymatic process, the SVF is released from the fat tissue, providing a rich, pure, more active mixture of stem cells. Among the population of cells in SVF are adipose-derived stem cells, which have an inherent ability to modulate the immune system through the release of paracrine factors that promote a systemic anti-inflammatory response. Through this specialized process, we can re-introduce your own stem cells systemically through IV infusion to:

  • Reduce systemic inflammation
  • Activate the endogeneous stem cell system to promote tissue repair and boost mobility
  • Promote greater vitality, energy and stamina

The Best Care & Safety

Treatment timeframes may vary slightly depending on the personalized plan, however, the procedures include three key steps:

  1. Day 1: Pre-operative session includes an office visit with the medical staff for a final detailed review of the patient’s treatment plan and answer any questions from the patient and family members.
  2. Day 2: The patient undergoes treatment and briefly rests in our comfortable facility before being escorted back to their hotel for the evening.
  3. Day 3: Post-operative session involves a brief physical at Okyanos and a discharge plan discussion. The physician reviews the post treatment recommendations, the follow up communication plan and clears the patient to go home.

For a more detailed understanding of what you can expect, watch our video series with Gretchen Dezelick, RN and Director of Clinical Operations.

The Procedure

Stem cell treatment at Okyanos is a minimally invasive, same-day outpatient procedure. Though recovery can and does vary from patient to patient, our protocols are designed and carried out with the goal of keeping “downtime” to a minimum. A general overview of the procedure is as follows:

  1. First, water-assisted fat harvesting is done to obtain a sufficient amount of adipose (fat) tissue.
  2. The unique blend of stem and regenerative cells which exist in the adipose tissue are then isolated and prepared for delivery using a proprietary closed/sterile, fully automated CGMP cell processing system. In about 65 minutes, the highly potent SVF is ready for IV infusion.
  3. Our expertly-trained medical staff will administer the SVF/stem cells intravenously (IV) to address systemic inflammation. Mannitol is optional to help the cells, and the anti-inflammatory factors that they release, cross the blood-brain barrier to potentially enhance a greater neurological effect.

For a more detailed understanding of what you can expect, watch our video series with Gretchen Dezelick, RN and Director of Clinical Operations.

For a detailed understanding of stem cell safety at Okyanos, watch our video below.

References:

An Update on Inflamm-Aging: Mechanisms, Prevention, and Treatment (July 2016) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963991/ (1)

Age-related inflammation triggers skeletal stem/progenitor cell dysfunction, (April 2019) https://www.pnas.org/content/116/14/6995 (2)

Inflammation Plays an Important Role in the Aging Process, NIH, National Institutes on Aging, https://www.nia.nih.gov/about/living-long-well-21st-century-strategic-directions-research-aging/inflammation-plays

Chronic inflammation in middle age may lead to thinking and memory problems later (February 2019) American Academy of Neurology, https://n.neurology.org/content/92/11/e1256

The integration of inflammaging in age-related diseases. (December 2018) Fulop T1, Witkowski JM2, Olivieri F3, Larbi A4. https://www.ncbi.nlm.nih.gov/pubmed/30287177