If you have a chronic wound, you know how painful and frustrating it is to not be able to heal.

Adult stem cell therapy is an effective new option for patients who are living with chronic, non-healing wounds as well as ischemia (lack of blood flow) in various tissues of the body as caused by conditions like heart disease and diabetes or autoimmune diseases such as lupus.

This innovative treatment utilizes adult stem cells (from your body fat) which have the ability to decrease inflammation, repair damaged tissue, facilitate better cell-to-cell communication and stimulate new blood vessel growth for better blood flow to the affected area(s). With Okyanos Cell Therapy, your body’s own natural repair mechanisms are put to work to accelerate healing and achieve for you a better quality of life.

What Are Chronic Wounds?

A chronic wound is a wound that does not heal in an orderly fashion or in a predictable amount of time the way most wounds do. Wounds that do not heal within three months are often considered chronic as they have become held up in one or more of the phases of wound healing.

Often wounds become chronic as a result of poor blood flow (ischemia), autoimmune dysfunction, degenerative conditions such as lupus or diabetes, radiation burns or even malnutrition. Heart and lung disease or peripheral arterial disease (PAD) can lead to chronic wounds because of related ischemia.

How Does Stem Cell Therapy Benefit Chronic Wounds?

A ready blood supply is essential for healing of wounds. Blood supplies the oxygen and nutrients necessary to restore health and vitality, and in fact your wounds can’t heal without it. The stem cells stored in your body fat have the capability of stimulating new blood vessel growth—a process which supplies wounds with sufficient blood for healing.

Your fatty tissue is also home to a mixed population of cells which are able to secrete vital growth factors. These are substances (like as a vitamin or a hormone) that are required for the normal process of wound healing to take place. The combination of these growth factors along with new blood vessel growth produces visible improvements of chronic wounds such as:

  • Decreased inflammation
  • Reduction of diameter and depth of ulcer
  • Decreased pain
  • Improved cosmetic appearance
  • In many cases, complete wound closure

The Procedure

Adult stem cell treatment at Okyanos is a minimally invasive, same-day outpatient procedure. Though recovery can and does vary from patient to patient, our protocols are designed and carried out with the goal of keeping “downtime” to a minimum. A general overview of the procedure is as follows:

  1. First, water-assisted fat harvesting is done to obtain about a cup of adipose (fat) tissue.
  2. The unique blend of stem and regenerative cells which exist in the adipose tissue are then isolated and prepared for intravenous delivery utilizing an EU-approved, closed/sterile, fully automated CGMP cell processing system. For patients receiving direct injections, a closed/sterile, manually operated cell processing technology will be used to obtain a micro-fragmented, cell-rich product for injection.
  3. Immediately thereafter, in accordance with the individualized treatment plan prepared for each patient, adult stem cells are delivered by direct injection to ischemic areas as well as intravenously to address the systemic factors relating to insufficient blood flow. This combination of IV and direct injection is a standard technique developed by doctors at Okyanos.

To learn more about Okyanos Cell Therapy for chronic wounds and other ischemic conditions, contact a Patient Liaison to request a free educational consultation or dial 855-OKYANOS (855-659-2667).

References

Effect of Human Adipose Derived Stem Cells on Scar Formation and Remodeling in a Pig Model: A Pilot Study (July 16, 2012) in Results and Conclusions. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/22804839

The Adipose-derived Stem Cell: Looking Back and Looking Ahead (June 1, 2010) in Molecular Biology of the Cell. Retrieved from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877637/

Therapy With Autologous Adipose-Derived Regenerative Cells for the Care of Chronic Ulcer of Lower Limbs in Patients with Peripheral Arterial Disease (March 20, 2013) in Journal of Surgical Research. Retrieved from: http://www.journalofsurgicalresearch.com/article/S0022-4804(13)00476-9/abstract

Mesenchymal Stem Cells Enhance Wound Healing Through Differentiation and Angiogenesis (July 5, 2007) in Stem Cells volume 25, issue 10, pages 2648-2659. Retrieved from http://onlinelibrary.wiley.com/doi/10.1634/stemcells.2007-0226/full

Treatment of Chronic Wounds With Bone Marrow-Derived Cells (April, 2003) in JAMA Dermatology (Archives of Dermatology). Retrieved from http://archderm.jamanetwork.com/article.aspx?articleid=479266